ISOD (Increasing solubility for oral delivery) improves solubility and reduces food effect by modifications of its physical states without any chemical reactions. Our key methods are solid dispersion using spray drying or co-precipitation to increase solubility of water-insoluble APIs.

Preparation of solid dispersion includes hydrophilic and/or pH-dependently water soluble and GRAS (Generally Recognized as Safe) polymers.

Preparation of granules using co-precipitation method implicates GRAS hydrophilic carriers which are quickly disintegrating and dissolving. Moreover, the finalized dosage forms reaching desired solubilities and dissolution profiles can be offered.

Our efficient solubilization techniques not only prevent thermal decomposition of APIs, but save cost and time for manufacture.